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Updated: May 13, 2026

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
Published on: April 13, 2014
Morphologic and morphometric bilateral analysis and sexual dimorphism in sciatic nerves of adult cadaveric specimens
Eric Simidi Kegoye1,2, Abdulfatai Olakunle Ojewale3, Winnie Ezekiel4,5
1Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O Box 71, Ishaka, Bushenyi, Uganda. ekegoye@gmail.com.
Background:
The Sciatic nerve (SN) exhibits distinct sex and side-related differences, which have significant implications for clinical practice. The study investigated the sex and side-related morphologic and morphometric variations of the nerve using cadavers.
Methods:
This is a cross-sectional cadaveric study involving 62 Ugandan cadavers. Continuous variables were reported using descriptive statistics and discrete variables were reported as percentages. Ordinary two-way ANOVA was used to compare the dimensions and proportion of the patterns of the SN.
Results:
The study identified six categories of exit patterns of the SN, type A ("Below and undivided") occurred in a majority of cases (62.9%). A penta-furcate branching pattern dominated the whole population. Bifurcate termination pattern was found in most SNs (90.3% and 87.1% for right and left limbs respectively) while the rest have the trifurcate termination pattern, with no side or sex-related variations. The average dimensions of SN were within normal ranges, and showed no side-related differences but with a sex difference (significantly higher in males than females), mean length of the SN in centimetres (length A: Males, right limbs = 30.58 ± 9.00; left limbs = 31.30 ± 6.20; Females, right = 26.07 ± 6.58; left = 26.30 ± 5.56). The difference in the length "A" for the males left limb and females right limb was statistically significant with a p-value of 0.0195.
Conclusions:
Most of the examined SNs showed normal anatomical characteristics with rare cases of sex-related dimorphism in the termination level and morphometry (length and diameter) of the nerve. The observed sexual dimorphisms in sciatic nerves are of clinical and surgical interest; hence, suggesting the need for further investigations in different populations, especially using advanced techniques such as ultrasonography anatomic techniques.
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