Effect of renal function on serum pro-gastrin-releasing peptide expression and its clinical relevance
Objective:
This study aims to evaluate the effect of renal function on serum pro-gastrin-releasing peptide (ProGRP) expression and to assess its clinical significance.
Materials And Methods:
A total of 3,906 individuals who underwent physical examinations at Peking Union Medical College Hospital between May 2017 and May 2020 were enrolled in this study. Participants were categorized into four groups based on their creatinine clearance rate (Ccr): the Ccr1 group (34 cases, < 30 mL/min), the Ccr2 group (715 cases, 30 - 60 mL/min), the Ccr3 group (2,289 cases, 60 - 90 mL/min), and the Ccr4 group (868 cases, > 90 mL/min). Levels of blood urea nitrogen (BUN), serum creatinine (Scr), cystatin C (Cys-C), and ProGRP were measured and compared across the groups. Additionally, endogenous Ccr values were calculated for all participants.
Results:
Serum levels of BUN, Scr, Cys-C, and ProGRP, as well as Ccr values, exhibited significant differences among the groups (p < 0.05). A negative correlation was found between Ccr and serum ProGRP (p = 0.001).
Conclusion:
Higher serum ProGRP levels were associated with more severe renal dysfunction. These findings underscore the importance of considering renal function when interpreting serum ProGRP levels for clinical diagnosis and prognosis.
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