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Pan-cancer analysis of DLAT reveals it as a prognostic Biomarker involved in immune infiltration of liver hepatocellular carcinoma

  • 0Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China.
Journal of Cancer +

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April 30, 2025

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April 30, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Dihydrolipoamide S-acetyltransferase (DLAT) is elevated in liver cancer, correlating with poor prognosis and increased immune cell infiltration. DLAT may be a potential therapeutic target for hepatocellular carcinoma (HCC).

Area Of Science

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background

  • Dihydrolipoamide S-acetyltransferase (DLAT) is a cuproptosis-related gene implicated in various cancers.
  • Its specific role and mechanisms in liver hepatocellular carcinoma (HCC) remain underexplored.

Purpose Of The Study

  • To investigate the association of DLAT expression with clinical features, prognosis, and biological functions in HCC.
  • To explore the relationship between DLAT, N6-methyladenosine (m6A) modification, and immune characteristics in HCC.

Main Methods

  • Bioinformatics analysis of DLAT expression, m6A modification, clinical data, and immune infiltration.
  • Immunohistochemistry (IHC) validation of DLAT expression in HCC tissues.
  • Correlation analysis with signaling pathways (PLK1, PI3K-AKT, Notch, WNT, Aurora B).

Main Results

  • Aberrant DLAT expression significantly impacts tumor prognosis and is linked to immune cell infiltration and immune checkpoint molecules (ICM).
  • A positive correlation was observed between DLAT expression and m6A regulatory factors in liver cancer.
  • DLAT expression is associated with key signaling pathways, including PLK1, PI3K-AKT, Notch, WNT, and Aurora B.

Conclusions

  • DLAT expression is significantly increased in HCC, associated with poor patient prognosis.
  • DLAT correlates with immune cell infiltration and ICM in HCC, suggesting an immunomodulatory role.
  • DLAT emerges as a potential therapeutic target for HCC.

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