Related Experiment Video
Updated: May 9, 2025
07:26
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
Published on: December 26, 2020
3.9K
When ASFV Infection Meets the cGAS-STING Signaling Pathway
Songbiao Chen1,2,3,4, Ke Shang1,2,3, Ying Wei1,2,3
1Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
Transboundary and Emerging Diseases
|April 30, 2025
Summary
African swine fever virus (ASFV) severely impacts pig populations. This review explores how ASFV interacts with the cGAS-STING innate immune pathway, detailing viral evasion strategies and potential therapeutic targets.
Area of Science:
- Veterinary Virology
- Immunology
- Molecular Biology
Background:
- African swine fever virus (ASFV) causes severe disease with high mortality in domestic and wild pigs.
- Innate immunity, particularly the cGAS-STING signaling pathway, is critical for host defense against viral infections.
- ASFV has evolved mechanisms to counteract host immune responses, including the cGAS-STING pathway.
Purpose of the Study:
- To review recent advancements in understanding the interplay between ASFV infection and the cGAS-STING pathway.
- To elucidate the molecular mechanisms by which ASFV interacts with and evades the cGAS-STING pathway.
- To identify potential avenues for developing novel vaccines and therapeutics against ASFV.
Main Methods:
- Literature review of recent studies on ASFV pathogenesis and host-pathogen interactions.
- Analysis of molecular mechanisms involving the cGAS-STING pathway during ASFV infection.
- Synthesis of current knowledge on ASFV immune evasion strategies.
Main Results:
- ASFV actively engages with and manipulates the cGAS-STING pathway.
- ASFV employs diverse strategies to evade cGAS-STING-mediated immunity, ensuring viral replication and survival.
- Understanding these interactions provides insights into ASFV pathogenesis.
Conclusions:
- The cGAS-STING pathway is a crucial battleground in ASFV infection.
- Targeting ASFV's manipulation of the cGAS-STING pathway offers promising strategies for vaccine and drug development.
- Further research into these molecular mechanisms is essential for controlling ASFV outbreaks.
