Related Experiment Video
Updated: May 5, 2026
08:29
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
16.0K
Genetic Alterations in War-Related Post-Traumatic Stress Disorder: A Systematic Review
Amir Hossein Rajabi1, Samaneh Zafarabadi2, Kimia Jazi3
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Bulletin of Emergency and Trauma
|April 30, 2025
Summary
Gene expression and DNA methylation changes are linked to war-related post-traumatic stress disorder (PTSD). Identified genes may offer targets for personalized PTSD treatments.
Area of Science:
- Molecular Psychiatry
- Neuroscience
- Genetics
Background:
- Post-traumatic stress disorder (PTSD), especially war-related, presents complex etiological factors.
- Understanding the molecular underpinnings of PTSD is crucial for developing effective treatments.
Purpose of the Study:
- To systematically review gene expression and DNA methylation patterns in war-related PTSD.
- To identify key molecular pathways and potential therapeutic targets for PTSD.
Main Methods:
- Comprehensive literature search of PubMed, Scopus, and Web of Science (2000-2024).
- Inclusion of studies on adult military personnel with DSM-5 diagnosed PTSD, using blood, saliva, or brain tissue.
- Exclusion of animal studies, interventions, and pharmacological research; data extraction from 28 studies.
Main Results:
- Upregulation of immune-related genes (e.g., CCL4, NF-κB) and hypomethylation of inflammation-related genes observed.
- Downregulation of neurodevelopmental genes (e.g., BDNF, DSCAM) indicates disrupted synaptic plasticity.
- Identified pathways suggest potential biomarkers and targets for precision medicine in PTSD.
Conclusions:
- Gene expression alterations play a significant role in war-related PTSD.
- Identified genes represent potential candidates for personalized PTSD therapies.
- Further research is needed to validate findings and develop targeted interventions.
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