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Identification and Phylogenetic Analysis of Mycobacterium avium subsp. avium Strain Isolated from Cow

Yanhong Bao1, Tianze Yang1, Hanxue Zhang1

  • 1College of Life Sciences, Jilin Agricultural University, Xincheng Street No. 2888, Changchun 130118, China.

Transboundary and Emerging Diseases
|April 30, 2025
PubMed

Insights

The first identification of Mycobacterium avium subsp. avium (MAA) in a cow reveals its potential risk to cattle. This finding supports MAA

Area of Science:

  • Veterinary Microbiology
  • Genomics
  • Zoonotic Diseases

Background:

  • Mycobacterium avium subsp. avium (MAA) is a primary cause of tuberculosis in poultry and wild birds.
  • MAA can infect mammals, including cattle, and poses a risk to immunocompromised individuals.

Purpose of the Study:

  • To report the first identification and characterization of MAA strain HJW isolated from a cow in China.
  • To perform phylogenetic analysis of the MAA strain HJW within the Mycobacterium avium complex (MAC).

Main Methods:

  • Whole genome sequencing of the MAA strain HJW.
  • Phylogenetic analysis using insertion sequence amplification and whole genome data.
  • Comparative genomic analysis with other MAC members.

Main Results:

  • Strain HJW was confirmed as MAA through genomic analysis.
  • The HJW genome is 4,961,843 bp with 69.28% GC content.
  • Strain HJW is phylogenetically closest to Mycobacterium avium subsp. avium strain DSM 44156.

Conclusions:

  • MAA poses an infection risk to cattle populations.
  • This study provides crucial data for understanding MAA phylogeny and its host range expansion.

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