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Updated: Jun 13, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Efficient thiol-ene click reactions of acryloyl-labeled carbohydrates on mammalian cell surfaces
Yasuhiko Iwasaki1,2, Yuto Tabe1, Ryosuke Tanaka1
1Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. yasu.bmt@kansai-u.ac.jp.
Abstract:
We present a method for noninvasive surface engineering of mammalian cells using thiol-ene click reactions with acryloyl-labeled carbohydrates. This optimized process allows rapid and efficient light-assisted ligation of thiol-bearing molecules on cells. Compared to methacryloyl analogues, acryloyl groups exhibited superior reactivity and versatility. Effective immobilization of DNA aptamers for targeted cell capture was enabled.

