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Published on: September 7, 2021
Knowledge, Attitudes, and Practices of the General Population Regarding Peripheral Blood Chromosomal Testing in the
Caixia Hu1, Lulu Zhai1, Hailian Wang1
1Hangzhou Linping District Maternal & Child Health Care Hospital, Hangzhou, China.
Insights
The general population shows low knowledge but positive attitudes and practices towards premarital blood chromosomal testing. Improving knowledge and attitudes can enhance testing uptake.
Area of Science:
- Reproductive Health
- Genetic Testing
- Public Health
Background:
- Previous studies focused on prenatal genetic testing, not premarital/preconception chromosomal testing.
- Limited data exists on public knowledge, attitudes, and practices (KAP) for premarital/preconception blood chromosomal testing.
Purpose of the Study:
- To investigate the KAP of the general population regarding peripheral blood chromosomal testing.
- To identify factors influencing KAP for premarital or preconception chromosomal testing.
Main Methods:
- A cross-sectional study was conducted from October to December 2023.
- 630 individuals undergoing free premarital or prepregnancy examinations completed a self-designed questionnaire.
- Data analysis included Mann-Whitney U, Kruskal-Wallis H, Pearson correlation, and multivariable logistic regression.
Main Results:
- Mean KAP scores were 63.00% for knowledge, 81.98% for attitude, and 83.69% for practice.
- Females exhibited higher attitude and practice scores than males.
- Knowledge and attitude scores were independently associated with practice scores.
Conclusions:
- The general population in Hangzhou has poor knowledge but favorable attitudes and practices regarding premarital/preconception blood chromosomal testing.
- Enhancing public knowledge and positive attitudes is crucial for improving testing practices.
Objectives:
Some previous studies examined the knowledge, attitudes, and practices (KAP) toward prenatal genetic testing of the fetus but not toward blood chromosomal testing in the preconception and premarital period. This study investigated the KAP of the general population regarding peripheral blood chromosomal testing in the premarital or preconception period.
Design:
A cross-sectional study.
Setting:
From October 2023 to December 2023 at the authors' hospital.
Participants:
Enrolled individuals who participated in free premarital medical examinations and free prepregnancy health examinations.
Primary And Secondary Outcome Measures:
A self-designed questionnaire (Cronbach's α = 0.917) was used to collect the demographic information and KAP scores. KAP scores across variable categories were analyzed using the Mann-Whitney U test or Kruskal-Wallis H test. Correlations between KAP scores were evaluated by Pearson correlation analysis. Factors associated with KAP were identified by multivariable logistic regression.
Results:
This study included 630 valid questionnaires. The mean knowledge, attitude, and practice scores were 18.90 ± 4.48 (/30, 63.00%), 40.99 ± 5.32 (/50, 81.98%), and 37.66 ± 4.43 (/45, 83.69%), respectively. The knowledge scores were similar between genders (p = 0.840). Compared with males, females had higher attitude scores (42.01 ± 5.40 vs. 40.01 ± 5.07, p < 0.001) and higher practice scores (38.17 ± 4.44 vs. 37.18 ± 4.37, p = 0.013). There were no significant differences between genders regarding the frequencies of having undergone chromosomal testing and recommending it to the partner. The knowledge scores (OR = 1.060, 95% CI: 1.018-1.103, p = 0.004) and attitude scores (OR = 1.198, 95% CI: 1.154-1.244, p < 0.001) were positively independently associated with the practice scores.
Conclusions:
The general population in Hangzhou displays poor knowledge but favorable attitudes and proactive practices regarding peripheral blood chromosomal testing in the premarital or preconception period. Cultivating proper knowledge and attitude should improve practice.
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