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pH distribution in human tumors.

A J Thistlethwaite, D B Leeper, D J Moylan

    International Journal of Radiation Oncology, Biology, Physics
    |September 1, 1985
    PubMed
    Summary
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    This study developed a safe method to measure tumor extracellular pH, finding it correlates with tumor size and treatment. Lower tumor pH may indicate better hyperthermia response.

    Area of Science:

    • Oncology
    • Biomedical Engineering
    • Medical Physics

    Background:

    • Tumor extracellular pH (pH) is lower than normal tissue, potentially impacting hyperthermia effectiveness.
    • Measuring tumor pH can serve as a prognostic indicator for hyperthermia response.
    • A novel technique for accurately measuring human tumor extracellular pH was developed.

    Purpose of the Study:

    • To devise and validate a technique for measuring extracellular pH in human tumors.
    • To assess the utility of tumor pH as a prognostic indicator for hyperthermia treatment.
    • To investigate correlations between tumor pH, size, and response to hyperthermia.

    Main Methods:

    • A 21-gauge needle electrode and an 18-gauge catheter were used for pH measurements in 14 human tumors.

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  • Saline wheals were employed for local anesthesia to avoid pH modification.
  • Tumor pH was measured before, during, and after hyperthermia sessions, with repeated measurements in the same locations.

    • Main Results:

    • 50 out of 53 pH readings were below normal physiological pH (average for unheated tumors: 6.81 ± 0.09).
    • Tumor pH demonstrated heterogeneity but was accurately measured; larger tumors tended to be more acidic.
    • Tumor pH increased with treatment sessions, and three of four tumors showed increased pH during heating.

    Conclusions:

    • The developed pH measurement technique is safe, easy, and reliable for human tumors.
    • Tumor extracellular pH is a potential prognostic indicator for hyperthermia response.
    • Tumor pH correlates with tumor size, treatment progression, and possibly blood flow.