Related Experiment Video
Updated: May 9, 2025

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
Published on: November 18, 2022
Anti-hypoxia polyacetylenes and sesquiterpenoids from Codonopsis pilosula (Franch.) Nannf
Zhuo-Yang Cheng1,2,3, Jun-Ge Jin1, Meng Yan1
1School of Pharmacy, Shanxi Medical University, Taiyuan, PR China.
Abstract:
A new polyacetylene, codonopsisylene (1), has been extracted from the roots of Codonopsis pilosula, along with 14 previously reported compounds, including two polyacetylenes (2-3) and twelve sesquiterpenoids (4-15). The chemical structures of these compounds were thoroughly characterised using a variety of spectroscopic techniques, combined with calculated NMR and ECD data. Anti-hypoxia activities of all isolated compounds were conducted using a CCK-8 assay. Among them, compounds 3 and 6 demonstrated anti-hypoxia effects by inhibiting ROS overexpression, reducing excessive LDH release and enhancing ΔΨm.
Related Concept Videos
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Radical Autoxidation
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...

