Related Experiment Video
Updated: May 9, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Highlights of 2024: Beyond lipids: immune dysfunction in APOE4-associated Alzheimer's disease
Isabella McEwan1,2, Shannon Thomson1,2, Jasmeen K Issar2,3
1Neurodegeneration and Precision Medicine Research Group, Westmead Institute for Medical Research, Westmead, NSW, Australia.
Abstract:
In this article for the "Highlights of 2024" Series, we discuss findings by our group and others that the Alzheimer's disease (AD) risk genetic variant apolipoprotein E ε4 (APOE4) is associated with peripheral immune dysregulation and chronic inflammation. We hypothesize that this leads to AD development via proinflammatory immune cells attacking the blood-brain barrier (BBB) to weaken it. Immune cells then infiltrate into the brain where they interact with brain cells to drive neuroinflammation, neurodegeneration, and AD pathology.
More Related Videos
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Alzheimer's Disease: Treatment

