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Published on: April 19, 2024
Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis
Qiqi Yan1,2, Guiling Liu1,2, Ruifeng Wang1,2
1Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Insights
High fibrinogen/albumin ratio (FAR) indicates a greater risk of first-ever cardiovascular events (CVE) in patients undergoing peritoneal dialysis (PD). This finding highlights FAR as a key indicator for cardiovascular risk in PD patients.
Area of Science:
- Nephrology
- Cardiology
- Biomarkers
Background:
- The fibrinogen/albumin ratio (FAR) is an emerging inflammatory marker linked to cardiovascular disease.
- The association between FAR and cardiovascular events (CVE) in peritoneal dialysis (PD) patients is not well-established.
Purpose of the Study:
- To investigate the relationship between the fibrinogen/albumin ratio (FAR) and the incidence of first-ever cardiovascular events (CVE) in patients receiving peritoneal dialysis (PD).
Main Methods:
- A cohort of 278 PD patients were categorized into high and low FAR groups based on the median value (0.107).
- Kaplan-Meier curves and Cox regression analyses were utilized to assess the association between FAR and first-ever CVE.
- Subgroup analyses were performed using forest plots.
Main Results:
- Over a mean follow-up of 40.26 months, 101 patients (36.3%) experienced a first-ever CVE.
- Higher FAR levels were significantly associated with an increased risk of first-ever CVE (p=0.002).
- Multivariate analysis identified FAR ≥ 0.107 and age as independent predictors of CVE risk in PD patients. ROC analysis confirmed FAR's predictive value.
Conclusions:
- Elevated fibrinogen/albumin ratio (FAR) is independently associated with a higher risk of first-ever cardiovascular events in patients on peritoneal dialysis.
- FAR serves as a valuable predictive biomarker for cardiovascular events in the PD population.
Objective:
The fibrinogen/albumin ratio (FAR) is a novel inflammatory indicator, which has been associated with cardiovascular disease. However, the relationship between FAR and cardiovascular event (CVE) in patients with peritoneal dialysis (PD) remains unclear. This study aims to clarify the relationship between FAR and first-ever CVE in patients with PD.
Methods:
A total of 278 patients were enrolled between January 2012 and June 2021. They were defined as the high FAR group and the low FAR group based on the median FAR value (0.107). The primary outcome was the occurrence of first-ever CVE. Kaplan-Meier's curves and Cox regression analysis were used to analyse the relationship between FAR and first-ever CVE in patients with PD. Forest plots were employed to depict the relationship between FAR and first-ever CVE in each subgroup.
Results:
The average follow-up period was 40.26 ± 28.27 months. A total of 101 (36.3%) patients developed first-ever CVE. Kaplan-Meier's analysis showed that there was a higher risk of first-ever CVE (p = .002) in the high FAR group. Multivariate Cox regression analysis showed that FAR ≥ 0.107 and age were independently associated with the risk of first-ever CVE in patients with PD. Receiver operating characteristic (ROC) analysis showed that FAR had a greater predicting value on the first-ever CVE.
Conclusions:
High levels of FAR are independently associated with an increased risk of first-ever CVE in patients with PD.
