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Related Experiment Video

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The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
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A flavonoid Ombuin ameliorates thioacetamide-mediated liver cirrhosis in vivo: biochemical, immunohistochemical,

Khaled Abdul-Aziz Ahmed1, Talal Salem Al-Qaisi2, Ahmed A J Jabbar3

  • 1Department of Basic Dental Sciences, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, 19328, Jordan.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|April 30, 2025
PubMed
Summary

Ombuin, a flavonoid, demonstrated significant hepatoprotective effects against thioacetamide-induced liver injury in rats. It reduced oxidative stress, inflammation, and apoptosis, showing promise as a viable treatment for hepatitis.

Keywords:
Antioxidant enzymesHistologyLiver cirrhosisOmbuinThioacetamide

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Toxicology

Background:

  • Liver cirrhosis presents a global health challenge, necessitating novel therapeutic strategies.
  • Thioacetamide (TAA) is a common inducer of experimental liver injury, mimicking aspects of human hepatitis.

Purpose of the Study:

  • To evaluate the acute toxicity and prophylactic effects of Ombuin, an O-methylated flavonoid, on TAA-induced liver injury in rats.
  • To elucidate the underlying mechanisms of Ombuin's hepatoprotective actions.

Main Methods:

  • Thirty Sprague-Dawley rats were divided into five groups: control, TAA-induced liver injury, silymarin + TAA, and two Ombuin + TAA doses (30 and 60 mg/kg).
  • Toxicity was assessed up to 500 mg/kg Ombuin.
  • Hepatic function, histopathology, oxidative stress markers (SOD, CAT, GPx, MDA), inflammatory cytokines (TNF-α, IL-6, IL-10), and apoptosis markers (PCNA, Bax) were analyzed.

Main Results:

  • Ombuin exhibited no toxicity up to 500 mg/kg.
  • TAA induced significant hepatotoxicity, characterized by altered tissue architecture, inflammation, oxidative stress, and apoptosis.
  • Ombuin treatment significantly reversed TAA-induced liver damage, restored liver functions, and modulated oxidative stress and apoptotic pathways.

Conclusions:

  • Ombuin possesses significant hepatoprotective properties against TAA-induced liver injury in rats.
  • Its efficacy is attributed to its anti-apoptotic, antioxidant, and anti-inflammatory potentials.
  • Ombuin is a promising candidate for developing hepatoprotective agents for inflammatory liver diseases.