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Updated: May 9, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury with cast nephropathy following creatine loading in a 17-year-old
Guido Filler1,2,3, Eugene Maung4, Maria Esther Díaz González de Ferris5
1Children's Health Research Institute, Western University, London, ON, N6 C 2 V5, Canada. guido.filler@lhsc.on.ca.
Abstract:
This case highlights a 17-year-old male who developed acute kidney injury (AKI) with cast nephropathy following a 6-day high-dose creatine loading regimen. The patient presented with bilateral flank pain, a parallel rise in cystatin C and creatinine, and kidney enlargement on ultrasound despite adequate hydration and the absence of rhabdomyolysis markers. Renal biopsy confirmed cast nephropathy without evidence of light chain disease. This case underscores the potential risks of high-dose creatine use in adolescents and highlights the importance of kidney function monitoring in athletes using sports supplements.
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