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Related Concept Videos

Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

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Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
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A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
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Related Experiment Video

Updated: May 9, 2025

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
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Introduction: Methods for Studying the Plasma Membrane and the Surfaceome.

Roland Takács1, Ali Mobasheri2,3,4,5, Csaba Matta6

  • 1Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Methods in Molecular Biology (Clifton, N.J.)
|April 30, 2025
PubMed
Summary

This volume details methods for studying the cell surfaceome, focusing on protein isolation, characterization, and interactions. It offers protocols for researchers to explore cell communication and signaling in health and disease.

Keywords:
Cell surfaceLaboratory protocolsMembrane biologyMembrane proteinsPlasma membraneSurfaceome

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Proteomics

Background:

  • The cell surfaceome is crucial for cell communication, adhesion, and signaling.
  • Understanding the surfaceome is vital in cell biology, biochemistry, and medicine.

Purpose of the Study:

  • To provide a comprehensive collection of protocols for exploring the dynamic nature of the cell surfaceome.
  • To equip researchers with methods for isolating, characterizing, and analyzing surface proteins and their interactions.

Main Methods:

  • Isolation and characterization of surface proteins.
  • Analysis of protein-protein interactions.
  • Investigation of posttranslational modifications.
  • Advanced techniques including single-channel recordings and mass spectrometry.

Main Results:

  • Detailed protocols are provided for various surfaceome analyses.
  • Troubleshooting tips are included to assist researchers.
  • The collection covers both established and emerging techniques.

Conclusions:

  • This resource empowers researchers to investigate the complexities of biological membranes and surfaceomes.
  • It supports research in understanding surfaceome roles in health and disease.