Related Experiment Video
Updated: May 8, 2025
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
A Single-Center Report of Hypertension in Native American Kidney Transplant Recipients
Ian P Rios1, Ahmed Elsaidi2, Danielle E Akin1
1Division of Nephrology and Hypertension, Mayo Clinic Arizona, 5777 E. Mayo Blvd, Phoenix, AZ, 85054, USA.
Insights
Hypertension is common in Native American kidney transplant recipients, with two-thirds experiencing uncontrolled blood pressure post-transplant. This highlights the need for focused hypertension management in this population.
Area of Science:
- Nephrology
- Cardiology
- Transplantation Medicine
Background:
- Hypertension affects 45% of US adults, and post-kidney transplant (KT) hypertension is linked to immunosuppression and poorer graft outcomes.
- Data on hypertension in Native American (NAm) KT recipients is limited, despite their significant presence at some transplant centers.
Purpose of the Study:
- To assess the prevalence and associated factors of hypertension in Native American kidney transplant recipients using ambulatory blood pressure monitoring.
- To evaluate hypertension control rates at 4 and 12 months post-transplant in this underserved population.
Main Methods:
- An observational study analyzing data from 262 Native American KT recipients transplanted between 2003 and 2023.
- Ambulatory blood pressure monitoring (AMBP) data at 4 and 12 months post-transplant were collected and analyzed.
Main Results:
- Average blood pressure was 133.0/76.2 mmHg at 4 months and 134.1/76.5 mmHg at 12 months.
- Male gender and older donor age were associated with hypertension at 4 months. Male gender and pre-transplant diabetes were associated with hypertension at 12 months.
- Approximately two-thirds of Native American KT recipients had uncontrolled hypertension at both 4 and 12 months post-transplant.
Conclusions:
- A significant burden of uncontrolled hypertension exists in Native American KT recipients, as indicated by AMBP.
- Targeted attention to hypertension management is crucial for improving outcomes in this minority patient group.
Abstract:
Based on the current American Heart Association/American College of Cardiology definition [systolic blood pressure (SBP) ≥ 130 and/or diastolic BP(DBP) ≥ 80], hypertension affects 45% of the adult U.S. population. Post-kidney transplant (KT) hypertension has been associated with immunosuppression and worse graft outcomes. Hypertension data on Native American (NAm) KT recipients (KTR) is scarce. In our center, we serve a significant NAm population, and measure ambulatory blood pressure (AMBP) routinely in KTR at 4- and 12-months post-transplant. In a noninterventional, observational study we queried our transplant database for all NAm KTR who were transplanted at our center between years 2003 and 2023. Patients who had 4- and/or 12-months AMBP were included in our study. 262 NAm KTR met inclusion criteria. Average (sd) BP was 133.0 (15.0)/76.2 (9.7) and 134.1 (15.6)/76.5 (9.9) at 4- and 12-months respectively. Male gender (p = 0.03) and older donor age (p = 0.02) were associated with BP ≥ 130/80 at 4-months. Male gender (p = 0.05) and pre-transplant diabetes (p = 0.01) were associated with BP ≥ 130/80 at 12-months. About two-thirds of NAm KTR had uncontrolled hypertension at 4- and 12-months. The burden of hypertension, as measured by the gold standard AMBP monitoring is significant in NAm KTR, and therefore, attention to hypertension management is prudent in this minority patient population.
More Related Videos
Related Concept Videos
01:33Hormonal Regulation
01:18Hypertension and Regulation of Blood Pressure
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
01:25Antihypertensive Drugs: Direct Renin Inhibitors
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors