Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling genetic mosaicism of the mammalian target of rapamycin pathway in the cerebral cortex.

Frontiers in mammal science·2026
Same author

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia.

Science advances·2025
Same author

Single nuclei transcriptomics reveals cellular diversity in TSC subependymal giant cell astrocytomas.

iScience·2025
Same author

A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model.

Scientific reports·2025
Same author

Relative roles of HCN4 and synaptic excitation in pyramidal neuron firing rates in a hyperactive Rheb-mTOR condition.

Epilepsia·2025
Same author

Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same journal

Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. <i>Biomolecules</i> 2022, <i>12</i>, 394.

Biomolecules·2026
Same journal

Correction: Kim, K.-H.; Yoo, B.C. Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. <i>Biomolecules</i> 2026, <i>16</i>, 465.

Biomolecules·2026
Same journal

Correction: Bastyte et al. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. <i>Biomolecules</i> 2024, <i>14</i>, 212.

Biomolecules·2026
Same journal

AtHSPR Plays a Positive Role in Arabidopsis Resistance Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 by Interacting with TOP1.

Biomolecules·2026
Same journal

CYTH4 Facilitates Renal Cell Carcinoma via Enhancing Proliferation and Likely Immune Evasion.

Biomolecules·2026
Same journal

Integrated Immune-Gut Profiling Identifies an Exploratory Pediatric Inflammatory Intestinal Profile Associated with Food-Specific IgG Reactivity.

Biomolecules·2026
See all related articles

Related Experiment Video

Updated: May 15, 2025

In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices
10:51

In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices

Published on: November 25, 2013

13.1K

TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment.

David M Feliciano1,2, Angelique Bordey3

  • 1Department of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USA.

Biomolecules
|April 30, 2025
PubMed
Summary
This summary is machine-generated.

Adult neurogenesis in the rodent brain

Keywords:
TSCTSC1TSC2mTORmTORC1neurogenesis

More Related Videos

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects
08:48

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Published on: February 17, 2016

9.2K
Neonatal Subventricular Zone Electroporation
08:06

Neonatal Subventricular Zone Electroporation

Published on: February 11, 2013

12.8K

Related Experiment Videos

Last Updated: May 15, 2025

In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices
10:51

In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices

Published on: November 25, 2013

13.1K
Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects
08:48

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Published on: February 17, 2016

9.2K
Neonatal Subventricular Zone Electroporation
08:06

Neonatal Subventricular Zone Electroporation

Published on: February 11, 2013

12.8K

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Adult neurogenesis persists in specific rodent brain regions, notably the ventricular-subventricular zone (V-SVZ).
  • Neural stem cells (NSCs) in the V-SVZ generate new neurons that integrate into the olfactory bulb.
  • This process is governed by genetic programs and influenced by signaling pathways.

Purpose of the Study:

  • To review the role of the mechanistic target of rapamycin (mTOR) pathway in V-SVZ neurogenesis.
  • To discuss the V-SVZ as a model for studying mTOR signaling in neurodevelopmental disorders.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of mTOR pathway involvement in neurogenesis.
  • Discussion of V-SVZ as a model system.

Main Results:

  • The mTOR pathway integrates nutrient and growth factor signals to regulate V-SVZ neurogenesis.
  • Dysregulation of mTOR signaling is implicated in various neurodevelopmental disorders.
  • The V-SVZ provides a valuable platform for investigating mTOR pathway function.

Conclusions:

  • The mTOR pathway is a critical regulator of adult neurogenesis in the V-SVZ.
  • Understanding mTOR signaling in the V-SVZ is crucial for addressing neurodevelopmental disorders.
  • The V-SVZ serves as a key region for studying mTOR in health and disease.