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TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment.
David M Feliciano1,2, Angelique Bordey3
1Department of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USA.
Biomolecules
|April 30, 2025
Summary
Adult neurogenesis in the rodent brain
Area of Science:
- Neuroscience
- Stem Cell Biology
- Molecular Biology
Background:
- Adult neurogenesis persists in specific rodent brain regions, notably the ventricular-subventricular zone (V-SVZ).
- Neural stem cells (NSCs) in the V-SVZ generate new neurons that integrate into the olfactory bulb.
- This process is governed by genetic programs and influenced by signaling pathways.
Purpose of the Study:
- To review the role of the mechanistic target of rapamycin (mTOR) pathway in V-SVZ neurogenesis.
- To discuss the V-SVZ as a model for studying mTOR signaling in neurodevelopmental disorders.
Main Methods:
- Narrative review of existing literature.
- Analysis of mTOR pathway involvement in neurogenesis.
- Discussion of V-SVZ as a model system.
Main Results:
- The mTOR pathway integrates nutrient and growth factor signals to regulate V-SVZ neurogenesis.
- Dysregulation of mTOR signaling is implicated in various neurodevelopmental disorders.
- The V-SVZ provides a valuable platform for investigating mTOR pathway function.
Conclusions:
- The mTOR pathway is a critical regulator of adult neurogenesis in the V-SVZ.
- Understanding mTOR signaling in the V-SVZ is crucial for addressing neurodevelopmental disorders.
- The V-SVZ serves as a key region for studying mTOR in health and disease.
