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Related Experiment Video

Updated: May 15, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

RNA-Mediated Non-Mendelian Inheritance in Mice: The Power of Memory.

Minoo Rassoulzadegan^1,2

¹Department of Medical Biology, Erciyes University, Kayseri 38039, Turkey.

|April 30, 2025

Summary

Early mouse development involves dynamic RNA metabolism and non-coding RNAs (ncRNAs) that regulate gene expression and cellular memory. These regulatory ncRNAs are crucial for embryonic genomic activation (EGA/ZGA) and adapting to environmental changes.

Keywords:

RNA cell memory genetic non-Mendelian inheritance phenotype

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Last Updated: May 15, 2025

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Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Area of Science:

Developmental Biology
Genomics
RNA Biology

Background:

Early embryonic development involves significant RNA metabolism and transcriptional changes.
Embryonic genomic activation (EGA/ZGA) establishes the initial RNA landscape in developing embryos.
Non-coding RNAs (ncRNAs) play critical roles in gene regulation and inheritance, but their functions are not fully understood.

Purpose of the Study:

To investigate the role of RNA metabolism and ncRNAs during early mouse embryonic development.
To understand how transcriptional variations influence cellular memory and developmental competence.
To highlight the significance of ncRNAs in regulating gene expression post-fertilization.

Main Methods:

Analysis of RNA transcription rates and metabolism in early mouse embryos.
Study of maternal RNA degradation during EGA/ZGA.
Investigation of ncRNA expression and function in response to environmental cues.
Microinjection experiments to assess RNA level modifications in fertilized mouse eggs.

Main Results:

RNA metabolism during EGA/ZGA creates blastomere heterogeneity.
ZGA-dependent maternal RNA degradation is essential for developmental competence.
Diverse regulatory ncRNAs are transcribed from the newly activated genome.
Rapid and significant transcript variations occur in response to environmental changes, impacting cellular memory.

Conclusions:

Regulatory ncRNAs are crucial for establishing and transmitting expression information during early development.
Dynamic changes in RNA content, driven by transcription, influence cellular memory even in a stable genome.
Understanding ncRNA diversity and function is vital for comprehending developmental plasticity and inheritance.