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Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Tropheryma whipplei Infections, Mexico, 2019-2021.

Jesús Delgado-de la Mora, Peter Grube-Pagola, Christopher D Paddock

    Emerging Infectious Diseases
    |April 30, 2025
    PubMed
    Summary

    Whipple's disease, a rare infection caused by Tropheryma whipplei, was diagnosed in two patients in Mexico. This highlights the need for increased clinical awareness of this rare bacterial infection and its syndromes.

    Keywords:
    MexicoTropheryma whippleiWhipple’s diseasebacteriaenteric infections

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    Area of Science:

    • Infectious Diseases
    • Gastroenterology
    • Microbiology

    Background:

    • Whipple's disease is a rare systemic infection caused by the bacterium Tropheryma whipplei.
    • Diagnosis is infrequent in Latin America, posing challenges for recognition and treatment.

    Purpose of the Study:

    • To report the first documented cases of Whipple's disease diagnosed in Mexico.
    • To emphasize the importance of considering Tropheryma whipplei infection in patients presenting with relevant clinical syndromes.

    Main Methods:

    • Histopathology and electron microscopy for tissue analysis.
    • Immunohistochemistry for specific Tropheryma whipplei detection.
    • 16S rRNA gene amplification and sequencing for definitive diagnosis.

    Main Results:

    • Two cases of Whipple's disease were successfully diagnosed in Mexico between 2019 and 2021.
    • Diagnostic methods confirmed the presence of Tropheryma whipplei in affected tissues.

    Conclusions:

    • Whipple's disease can occur in Latin America, despite its rarity.
    • Clinicians should maintain a high index of suspicion for Tropheryma whipplei infection and its associated clinical manifestations.