Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

478
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
478
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

362
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
362
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

385
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
385

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraocular pressure distribution in old and young cynomolgus monkeys following general anesthesia and mydriasis.

Molecular vision·2026
Same author

Pseudomyopia and cycloplegic changes in young cynomolgus macaques.

Molecular vision·2026
Same author

Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length.

Investigative ophthalmology & visual science·2025
Same author

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization.

Translational vision science & technology·2025
Same author

Global, regional, and national burden of retinoblastoma in infants and young children: findings from the global burden of disease study 1990-2021.

EClinicalMedicine·2024
Same author

Relationships between Frailty and the Risk of Glaucoma in Middle-aged and Older Adults.

Ophthalmology. Glaucoma·2024

Related Experiment Video

Updated: May 12, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.2K

Risk for ocular hypertension progression to early glaucoma: A predictive model and key predictors.

Shaofen Huang1, Man Luo2, Guitong Ye1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, PR China.

Photodiagnosis and Photodynamic Therapy
|April 30, 2025
PubMed
Summary

A new model accurately predicts ocular hypertension (OHT) progression to glaucoma using key predictors like intraocular pressure and retinal layer thickness. This tool aids in personalized glaucoma treatment plans.

Keywords:
Early glaucomaOCTOcular hypertensionPredictive modelRisk stratification

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.2K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.3K

Related Experiment Videos

Last Updated: May 12, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.2K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.2K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.3K

Area of Science:

  • Ophthalmology
  • Medical Informatics
  • Glaucoma Research

Background:

  • Ocular hypertension (OHT) is a primary risk factor for developing glaucoma.
  • Early detection of glaucoma progression from OHT is crucial for timely intervention.

Purpose of the Study:

  • To develop a predictive model for ocular hypertension progression to early glaucoma.
  • To identify key clinical and imaging predictors of glaucoma development.

Main Methods:

  • A random forest machine learning model was developed using patient data.
  • Predictors were selected using regression techniques and model performance was evaluated with AUC and AP metrics.
  • Shapley additive explanations were used for model interpretability.

Main Results:

  • The random forest model demonstrated high predictive accuracy (AUC up to 0.937 in testing set).
  • Key predictors included baseline intraocular pressure, rim area, and ganglion cell-inner plexiform layer thickness differences.
  • Family history and male sex were also identified as contributing factors.

Conclusions:

  • The developed model effectively predicts the risk of OHT progressing to early glaucoma.
  • This tool can assist in creating individualized treatment and follow-up strategies for OHT patients.