Deep Learning-Powered Whole Slide Image Analysis in Cancer Pathology

Pathology is the cornerstone of modern cancer care. With the advancement of precision oncology, the demand for histopathologic diagnosis and stratification of patients is increasing as personalized cancer therapy relies on accurate biomarker assessment. Recently, rapid development of whole slide imaging technology has enabled digitalization of traditional histologic slides at high resolution, holding promise to improve both the precision and efficiency of histopathologic evaluation. In particular, deep learning approaches, such as Convolutional Neural Network, Graph Convolutional Network, and Transformer, have shown great promise in enhancing the sensitivity and accuracy of whole slide image (WSI) analysis in cancer pathology because of their ability to handle high-dimensional and complex image data. The integration of deep learning models with WSIs enables us to explore and mine morphologic features beyond the visual perception of pathologists, which can help automate clinical diagnosis, assess histopathologic grade, predict clinical outcomes, and even discover novel morphologic biomarkers. In this review, we present a comprehensive framework for incorporating deep learning with WSIs, highlighting how deep learning-driven WSI analysis advances clinical tasks in cancer care. Furthermore, we critically discuss the opportunities and challenges of translating deep learning-based digital pathology into clinical practice, which should be considered to support personalized treatment of cancer patients.