Nuclear Receptor-Binding SU(VAR)3-9, Enhancer of Zeste, Trithorax Domain Structural Domain Protein 2 Serves as a Potential Prognostic Biomarker in Mantle Cell Lymphoma
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View abstract on PubMed
Summary
This summary is machine-generated.Nuclear receptor-binding SET structural domain protein 2 (NSD2) mutations and high expression are linked to aggressive mantle cell lymphoma (MCL) and poor prognosis. NSD2 is a potential prognostic marker and therapeutic target in MCL.
Area Of Science
- Oncology
- Molecular Biology
- Hematology
Background
- Nuclear receptor-binding SET structural domain protein 2 (NSD2) is implicated in various cancers.
- NSD2 mutations and overexpression contribute to tumor progression and poor outcomes.
- The clinical significance of NSD2 in mantle cell lymphoma (MCL) requires further elucidation.
Purpose Of The Study
- To investigate the role and clinical significance of NSD2 mutations and expression in MCL.
- To evaluate NSD2 as a prognostic marker and potential therapeutic target in MCL.
Main Methods
- Analysis of Next Generation Sequencing data from 147 MCL patients.
- Immunohistochemical evaluation of NSD2 protein expression in 39 MCL patients.
- Bioinformatic analysis of cBioPortal and Gene Expression Omnibus (GSE93291) databases.
- Tumor-infiltrating immune cell analysis using CIBERSORT.
Main Results
- NSD2 mutations identified in 8.84% of MCL cases, predominantly with bone marrow involvement.
- High NSD2 protein expression correlated with higher MCL International Prognostic Index scores, poorer treatment response, and reduced survival.
- NSD2 expression associated with aggressive histologic variants, elevated c-MYC, and high Ki-67 proliferation index.
- NSD2 mutations, particularly E1099K and T1150A, linked to poorer prognoses.
- Elevated NSD2 mRNA expression correlated with MKI67 and reduced survival rates.
- Increased intratumoral regulatory T cells associated with NSD2 expression.
Conclusions
- NSD2 mutations and high expression indicate aggressive biological behavior in MCL.
- Higher NSD2 mRNA and protein levels are associated with a worse prognosis in MCL.
- NSD2 serves as a valuable prognostic marker and a potential therapeutic target for MCL.
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