Effect of BMI on the risk of postoperative complications following total hip arthroplasty

While obesity is associated with an increased risk of complications after total hip arthroplasty (THA), the relationship between BMI and the risk of early postoperative complications has not been fully characterized. This study sought to describe the relationship between BMI and the risk of early postoperative complications, including periprosthetic joint infection (PJI), and composite surgical and composite medical complications.

Primary, elective THAs performed from 1 October 2015 to 31 December 2021 were identified using the Premier Healthcare Database. The study's primary outcome was the diagnosis of PJI within 90 days of THA. Using BMI as a continuous variable, logistic regression was used to develop restricted cubic splines (RCSs) to determine the impact of BMI on PJI risk. Bootstrap simulation was used to identify an inflection point in the final RCS model. The same technique was used to characterize the effects of BMI on composite medical and surgical complications.

We found that PJI risk increased exponentially beyond a BMI threshold of 37.4 kg/m². Relative to this threshold, patients with a BMI of 40 or 50 kg/m² were at a 1.22-fold and 2.55-fold increased risk of developing PJI, respectively. Surgical complications increased at a BMI of 32 kg/m² and medical complications increased at a BMI of 39 kg/m². Relative to these cut points, patients with a BMI of 50 kg/m² were at a 1.36-fold and 2.07-fold increased risk of developing medical and surgical complications, respectively.

The results of this study indicate a non-linear relationship between patient BMI and early postoperative risk of PJI, composite medical complications, and composite surgical complications following THA. The identified cut points with associated odds ratios can serve as tools to help risk-stratify and counsel patients seeking primary THA.