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Task Modulation of Resting-State Functional Gradient Stability in Lifelong Premature Ejaculation: An FMRI Study
Jiaming Lu1, Qing Hu1, Yan Lei1
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Eneuro
|April 30, 2025
Summary
Premature ejaculation (PE) involves altered brain function. This study found increased brain network stability in specific regions after erotic tasks in men with PE, suggesting salience and default mode network dysfunction.
Area of Science:
- Neuroscience
- Brain Imaging
- Sexual Health
Background:
- Lifelong premature ejaculation (LPE) is linked to abnormal brain function, indicated by functional MRI (fMRI) studies.
- Understanding brain network dynamics in LPE is crucial for developing targeted interventions.
Purpose of the Study:
- To investigate the stability of brain network architectures in resting-state conditions after erotic task perturbation in individuals with LPE.
- To compare dynamic functional connectome and gradient mapping between LPE patients and normal controls (NCs).
Main Methods:
- Resting-state fMRI data acquired before and after erotic tasks in 28 LPE patients and 17 NCs.
- Dynamic functional connectome analysis using phase-locking algorithm and ROI-wise gradient mapping.
- Linear mixed effects models used to assess gradient stability across task conditions.
Main Results:
- Both LPE and NC groups showed unimodal to transmodal transitions in the principal gradient and network segregation in the secondary gradient.
- LPE patients exhibited significantly increased stability in the bilateral dorsal prefrontal cortex and right temporo-occipital-parietal cortex post-task.
- Changes in gradient stability correlated significantly with sexual behavior.
Conclusions:
- Brain functional gradients demonstrate distinct patterns in LPE and NCs.
- Increased gradient stability in specific prefrontal and temporo-occipital-parietal regions in LPE patients suggests altered neural processing.
- Dysfunction in salience and default mode networks may underlie delayed recovery from stimulation in LPE.
