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[Studies on Formulations from a Clinical Perspective].

Takahiro Uchida1

  • 1Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Science, Mukogawa Women's University.

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|April 30, 2025
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Summary

Researchers developed advanced taste sensors for bitter drug evaluation and novel drug delivery systems using poly(lactic-co-glycolic acid) (PLGA). They also created predictive models for injectable formulations, improving patient treatment safety and efficacy.

Keywords:
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Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Engineering
  • Drug Delivery Systems

Background:

  • This review summarizes research from April 2002 to March 2024 at Mukogawa Women's University.
  • The research spans three key areas: taste sensing for oral medications, poly(lactic-co-glycolic acid) (PLGA) based drug delivery, and clinical evaluation of injectables.

Purpose of the Study:

  • To quantitatively assess oral medication bitterness using taste sensors and correlate with human taste receptors.
  • To develop advanced drug delivery systems with poly(lactic-co-glycolic acid) (PLGA) for sustained release and therapeutic effects.
  • To create predictive systems for injectable formulation stability and clinical efficacy.

Main Methods:

  • Utilized taste sensors with lipid/polymer membranes (2,6-dihydroxybenzoic acid modified) for bitterness evaluation.
  • Engineered poly(lactic-co-glycolic acid) (PLGA) microspheres and polymeric micelles for sustained drug release and therapeutic applications.
  • Developed quantitative predictive models for injectable particle formation and clinical efficacy using MIC values and nomograms.

Main Results:

  • Taste sensor demonstrated high accuracy in predicting bitterness, correlating with human taste receptor hT2R14.
  • Poly(lactic-co-glycolic acid) (PLGA) systems achieved one-month sustained release of prostaglandin derivatives.
  • PLGA-based micelles showed antibacterial activity and anti-cancer proliferation effects; predictive systems for injectables were established.

Conclusions:

  • Advanced taste sensing technology enhances the evaluation of oral medication palatability.
  • Poly(lactic-co-glycolic acid) (PLGA) based drug delivery systems offer promising therapeutic potential.
  • Predictive modeling improves the safety and clinical efficacy of injectable pharmaceutical formulations.