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Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

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The intratumoral balance of IgG4⁺ plasma cells and CD8⁺ T cells is associated with prognosis of intrahepatic

Yu-Hang Ye¹, Hao-Yang Xin¹, Ning Li²

¹Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

|April 30, 2025

Summary

Tumor-infiltrating IgG4-positive plasma cells indicate poor prognosis in intrahepatic cholangiocarcinoma (iCCA). The ratio of IgG4-positive plasma cells to CD8-positive T cells is a significant predictor of survival in iCCA patients.

Keywords:

CD8(+) T cells IgG4(+) plasma cells Intrahepatic cholangiocarcinoma Prognosis

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Area of Science:

Immunology
Oncology
Gastroenterology

Background:

The tumor microenvironment significantly impacts intrahepatic cholangiocarcinoma (iCCA) progression and prognosis.
The specific role of IgG4-positive plasma cells in iCCA remains largely unexplored.

Purpose of the Study:

To investigate the prognostic value of IgG4-positive plasma cells in iCCA.
To explore the association between IgG4-positive plasma cells and T cell subsets (CD3, CD4, CD8, Foxp3) in iCCA.

Main Methods:

Immunohistochemistry was used to stain IgG4-positive plasma cells and T cell subsets.
Kaplan-Meier survival analysis was performed to assess prognostic significance.
Patients were stratified into groups based on IgG4-positive plasma cell and CD8-positive T cell ratios.

Main Results:

Tumor-infiltrating IgG4-positive plasma cells, but not those in adjacent tissue, correlated with poor iCCA prognosis.
The number of IgG4-positive plasma cells showed an association with CD8-positive T cells.
A higher IgG4-positive/CD8-positive T cell ratio was an independent risk factor for recurrence-free and overall survival.

Conclusions:

IgG4-positive plasma cell distribution within iCCA tumors has prognostic utility.
Combining IgG4-positive plasma cell and CD8-positive T cell distribution enhances prognostic prediction in iCCA.