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Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs
Tailin He1,2,3, Lei Qin4, Sheng Chen5
1Department of Rheumatology and Immunology, Shenzhen Third People's Hospital, Shenzhen, 518112, China.
Bone Research
|April 30, 2025
Summary
Bone secretes factors that regulate systemic metabolism and impact various organs. Understanding these bone-derived factors (BDFs) is key to developing new therapies for diverse diseases.
Area of Science:
- Endocrinology
- Metabolic Research
- Skeletal Biology
Background:
- Bone is traditionally viewed for structural support.
- Emerging evidence highlights bone's role in systemic metabolic regulation.
- Bone secretes diverse molecules known as bone-derived factors (BDFs).
Purpose of the Study:
- To review the current understanding of BDFs' regulatory roles in various organs.
- To explore BDFs' involvement in the pathogenesis of multiple diseases.
- To highlight the therapeutic potential of targeting bone secretomes.
Main Methods:
- Literature review of current research on BDFs.
- Analysis of BDFs' effects on gene regulation and signaling pathways.
- Examination of BDFs' roles in disease pathogenesis.
Main Results:
- BDFs modulate critical genes and signaling pathways in vivo.
- BDFs are implicated in diseases of the musculoskeletal, circulatory, metabolic, nervous, urinary, and reproductive systems.
- Bone functions as a multifunctional endocrine organ.
Conclusions:
- BDFs are crucial mediators of systemic metabolism and organ function.
- Further research into BDFs can lead to novel therapeutic strategies.
- Understanding bone's endocrine role is vital for human health.
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