Comparative study of microneedle insertion across different skin models

Microneedles (MNs) enhance drug delivery by painlessly penetrating the stratum corneum, with hardness being crucial for safe insertion. While human/animal skins and synthetic materials are used to test MNs, their variability affects results. Finite element methods (FEM) simulate insertion, but skin model complexity and software limitations cause inconsistencies. This study employs FEM to compare MN performance across skun models under uniform conditions. Results reveal small volume change differences during insertion and rank penetration ease for human/animal models, aiding skin model selection and species-specific MN design optimization.