Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.7K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.7K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

3.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient separation of large particles and giant cancer cells using an isosceles trapezoidal spiral microchannel.

The Analyst·2024
Same author

Organ-on-a-Chip for Studying Gut-Brain Interaction Mediated by Extracellular Vesicles in the Gut Microenvironment.

International journal of molecular sciences·2021
Same author

Systematic Review: Microfluidics and Plasmodium.

Micromachines·2021
Same author

3D-Printed Modular Microfluidic Device Enabling Preconcentrating Bacteria and Purifying Bacterial DNA in Blood for Improving the Sensitivity of Molecular Diagnostics.

Sensors (Basel, Switzerland)·2020
Same author

Integrated Microfluidic Preconcentration and Nucleic Amplification System for Detection of Influenza A Virus H1N1 in Saliva.

Micromachines·2020
Same author

Cell Seeding Technology for Microarray-Based Quantitative Human Primary Skeletal Muscle Cell Analysis.

Analytical chemistry·2019
Same journal

Nanotechnology-Stem Cell Strategies in 3D Glioblastoma Organoid: Targeting Glioma Stem Cells Within a Complex Tumor Microenvironment.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: May 9, 2025

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10:30

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Published on: August 4, 2022

2.7K

Utility of Induced Pluripotent Stem Cell-Based Microphysiological Systems for Drug Development and Testing.

Danny van Noort1, Carl-Fredrik Mandenius2

  • 1Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

Methods in Molecular Biology (Clifton, N.J.)
|April 30, 2025
PubMed
Summary
This summary is machine-generated.

Microphysiological systems (MPS) offer a promising avenue for drug development by mimicking human organs. Further refinement is needed to enhance their biological functionality for accurate drug testing.

Keywords:
Conceptual designDrug assessmentIn vivo-likeMicrofluidicsMicroplatesMicrosensorsOrgan-on-a-chipOrganoidsStem cells

More Related Videos

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

1.7K
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.2K

Related Experiment Videos

Last Updated: May 9, 2025

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10:30

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Published on: August 4, 2022

2.7K
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

1.7K
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.2K

Area of Science:

  • Biotechnology
  • Drug Development
  • Tissue Engineering

Background:

  • Microphysiological systems (MPS) are miniaturized biological mimics designed to replicate organ and tissue functions.
  • Current MPS development often prioritizes microarchitecture and technological design over biological functionality.
  • The potential of MPS to accelerate drug development hinges on their ability to accurately model in vivo responses.

Purpose of the Study:

  • To discuss the essential prerequisites for designing and constructing MPS for drug development.
  • To evaluate the utility of MPS in a holistic manner for drug testing.
  • To highlight limitations and areas for improvement in current MPS technology.

Main Methods:

  • Discussion of design and construction prerequisites for MPS.
  • Consideration of induced pluripotent cells for mimicking in vivo disease conditions.
  • Analysis of existing limitations and recent advancements in MPS technology.

Main Results:

  • MPS show potential for drug development if they can accurately mimic organ responses and allow cellular monitoring.
  • Technological advancements in MPS design have sometimes overshadowed biological relevance.
  • Induced pluripotent cells are a key source for modeling disease states in MPS.

Conclusions:

  • Optimizing MPS design requires a holistic approach balancing technological sophistication with biological fidelity.
  • Further improvements are necessary to fully realize the potential of MPS in drug development and testing.
  • The use of induced pluripotent cells holds significant promise for enhancing the in vivo relevance of MPS models.