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Measuring Local Anaphylaxis in Mice
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Neurocognitive manifestation after treatment of pediatric severe anaphylaxis

Benjamin Nti1, Sheryl Allen2

  • 1Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA. bnti@iu.edu.

BMC Neurology
|April 30, 2025
PubMed

Insights

Severe allergic reactions, known as anaphylaxis, can rarely cause lasting neurological problems. Recognizing these rare neurological complications is crucial for effective patient management and improved outcomes.

Area of Science:

  • Allergy and Immunology
  • Neurology

Background:

  • Anaphylaxis is a severe, rapid-onset allergic reaction affecting multiple body systems.
  • Rarely, anaphylaxis can lead to poorly understood neurological manifestations.

Purpose of the Study:

  • To highlight a rare case of prolonged neurological deficits following severe anaphylaxis.
  • To increase clinician awareness of potential neurological complications of anaphylaxis.

Main Methods:

  • Case report of a 14-year-old male with severe anaphylaxis.
  • Detailed description of subsequent neurological deficits during recovery.

Main Results:

  • The patient experienced severe anaphylaxis requiring critical care.
  • Prolonged neurological deficits including weakness, prosopagnosia, and amnesia developed post-anaphylaxis.

Conclusions:

  • Rare neurological manifestations following anaphylaxis can be overlooked.
  • Emphasizing this complication is vital for enhancing anaphylaxis patient care.
Abstract

Keywords:
AllergyAmnesiaAnaphylaxis

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