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GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer

Yibin Pan1,2,3, Lingfeng Chen1,2,3,4, Jinlu Shen1,2,3

  • 1Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Cell Proliferation
|May 1, 2025
PubMed

Insights

GANT61 triggers autophagy and lipid droplet accumulation through the AKT/SREBP1 pathway. Combining GANT61 with CQ/Fatostatin effectively inhibits cancer cell growth and clonogenicity.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Autophagy plays a complex role in cancer, influencing cell survival and drug resistance.
  • Lipid metabolism is increasingly recognized as a critical factor in cancer progression and therapeutic vulnerability.

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