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Motivations and Preferences for Self-Sampled Human Papillomavirus Testing Among Average-and High-Risk Patients: An
Rebecca Morgis1, Ashley Wong1, Lisa M Witmer1
1Penn State College of Medicine, Hershey, Pennsylvania, USA.
Women'S Health Reports (New Rochelle, N.Y.)
|May 1, 2025
Summary
At-home human papillomavirus (HPV) testing is acceptable for cervical cancer screening. Most patients prefer self-sampled HPV tests, showing potential to improve screening rates.
Area of Science:
- Oncology
- Public Health
- Gynecology
Background:
- Cervical cancer screening rates are below national targets, necessitating innovative approaches.
- At-home self-sampled human papillomavirus (HPV) testing offers a potential solution to increase screening participation.
Purpose of the Study:
- To assess the acceptability of at-home self-sampled HPV testing.
- To explore motivating factors and preferences for HPV testing modality among average-risk and high-risk patients.
Main Methods:
- A cross-sectional study involving 46 female participants (ages 30-65) who had previously undergone clinician-collected screening.
- Participants completed an at-home self-sampled HPV test and a survey assessing motivators and test preference.
- Analysis focused on the relationship between motivating factors and preference for future cervical cancer screening methods.
Main Results:
- A majority of participants (57%) preferred at-home self-sampled HPV testing for future screenings.
- Few participants reported negative feelings (e.g., discomfort, anxiety) during the self-sampling process.
- Preference for self-sampled HPV testing did not significantly differ between average-risk and high-risk patient groups.
Conclusions:
- At-home self-sampled HPV testing demonstrates high acceptability across different patient risk groups.
- This method shows promise as an effective strategy to enhance cervical cancer screening rates, including for high-risk populations.

