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Related Concept Videos

Menopause01:28

Menopause

94
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
94
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

183
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
183
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

311
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
311

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Related Experiment Video

Updated: May 9, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
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Validating At-Home Urinary Hormone Measurements in Postpartum and Perimenopause Fertility Transitions.

Thomas P Bouchard1,2, Patricia K Doyle-Baker3, Paul J Yong2

  • 1Department of Family Medicine, University of Calgary, Calgary, Canada.

Women'S Health Reports (New Rochelle, N.Y.)
|May 1, 2025
PubMed
Summary

Quantitative fertility monitors like Mira can help women track postpartum and perimenopause transitions. The Mira monitor accurately identifies luteinizing hormone (LH) surges and estrone-3-glucuronide (E13G) levels, correlating with other fertility monitors.

Keywords:
estrone-3-glucuronide (E13G)luteinizing hormone (LH)menstrual cycleovulationperimenopausepostpartum

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Area of Science:

  • Reproductive endocrinology
  • Biomarker detection
  • Fertility monitoring technologies

Background:

  • Home-based quantitative menstrual cycle hormone monitoring offers insights into fertility transitions.
  • Validation of quantitative fertility monitors is crucial for accurate self-assessment.
  • Postpartum and perimenopause represent key periods of fertility transition.

Purpose of the Study:

  • To validate the Mira fertility monitor's quantitative hormone measurements.
  • To assess the correlation between Mira monitor data and ClearBlue Fertility Monitor (CBFM) readings.
  • To evaluate the utility of quantitative hormone tracking during postpartum and perimenopause.

Main Methods:

  • 16 North American women (aged 28-51) were studied during postpartum or perimenopause.
  • Daily first-morning urine testing was performed using Mira Monitor and CBFM.
  • Menstrual cycle parameters were tracked alongside hormone level measurements.

Main Results:

  • High correlation (R=0.94, R=0.83) was observed in identifying ovulation day via LH surge on both monitors.
  • Mira's estrone-3-glucuronide (E13G) levels were significantly higher for CBFM's 'High' vs. 'Low' readings.
  • Mira's luteinizing hormone (LH) levels were significantly higher for CBFM's 'Peak' vs. 'High' readings.

Conclusions:

  • The Mira monitor accurately identifies LH surges and E13G levels during fertility transitions.
  • Quantitative hormone data from Mira strongly correlates with CBFM readings.
  • Mira monitor shows potential for reliable fertility tracking in postpartum and perimenopause.