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Reactive oxygen species-dependent nanomedicine therapeutic modalities for gastric cancer
Zhiyan Li1, Yanjun Lu2, Lulu Wang1
1Department of Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China wangtao_pumc@live.cn.
Abstract:
Reactive oxygen species (ROS) play a double-edged role in gastric cancer (GC). Higher levels of ROS in tumor cells compared to normal cells facilitate tumor progression. Once ROS concentrations rise rapidly to toxic levels, they cause GC cell death, which is instead beneficial for GC treatment. Based on these functions, nano-delivery systems taking the therapeutic advantages of ROS have been widely employed in tumor therapy in recent years, overcoming the drawbacks of conventional drug delivery techniques, such as non-specific systemic effects. In this review, the precise impacts of ROS on GC have been detailed, along with ROS-based nanomedicine therapeutic schemes. These strategies mainly focused on the use of excess ROS in the tumor microenvironment for controlled drug release and a substantial enhancement of ROS concentrations for tumor killing. The challenges and opportunities for the advancement of these anticancer therapies are also emphasized.
Insights
Reactive oxygen species (ROS) have a dual role in gastric cancer (GC). ROS-based nanomedicine offers targeted cancer therapy by controlling ROS levels for tumor cell death.
Area of Science:
- Oncology
- Nanomedicine
- Biochemistry
Background:
- Reactive oxygen species (ROS) exhibit a dual role in gastric cancer (GC) progression and treatment.
- Elevated ROS levels in tumor cells promote GC, while toxic ROS concentrations induce cancer cell death.
Purpose of the Study:
- To review the precise impacts of ROS on GC.
- To detail ROS-based nanomedicine strategies for GC therapy.
- To highlight challenges and opportunities in ROS-based anticancer therapies.
Main Methods:
- Review of existing literature on ROS in GC.
- Analysis of nanomedicine approaches utilizing ROS for cancer treatment.
- Examination of strategies for controlled drug release and ROS enhancement.
Main Results:
- ROS levels influence GC progression and therapeutic outcomes.
- Nanodelivery systems leverage ROS for targeted GC therapy, overcoming conventional drug delivery limitations.
- Strategies focus on exploiting tumor microenvironment ROS for drug release and tumor cell killing.
Conclusions:
- ROS-based nanomedicine presents a promising therapeutic avenue for GC.
- Targeted manipulation of ROS offers enhanced efficacy and reduced systemic toxicity.
- Further research is needed to address challenges and advance ROS-targeted GC therapies.
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