Neuropsychiatric Symptoms and Mortality in Cognitively Normal Older Mexican Americans

Neuropsychiatric symptoms (NPS) present in older adults with Alzheimer's disease (AD) and other dementias are related to mortality. Research on the relationship between NPS and mortality in a non-dementia population is limited. This study examines NPS as a predictor of six-year mortality among community dwelling Mexican Americans aged 80 years and older. Data included 466 cognitively normal participants from Wave 7 of the Hispanic Established Population for the Epidemiological Study of Elderly. NPS were measured using the Neuropsychiatric inventory (NPI). Cox proportional hazard models were used to estimate the hazard ratio (HR) of mortality. The HR of death at 6 years was 1.02 (95% Confidence Interval-CI [1.00, 1.04]) as a function of NPI score and 1.09 (95% CI [1.02, 1.17]) for the number of NPI conditions, controlling for demographic and health characteristics. Apathy, irritability, and aberrant motor behavior were all independently predictors of mortality. NPS may be modifiable risk factors to increase survival time or may be indicative of underlying health problems. NPS may be related to underlying health conditions among older adults with normal cognitive functioning.