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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: May 9, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Cholestasis in hepatitis E virus infection.

Tatsuo Kanda1, Reina Sasaki-Tanaka2, Takeshi Yokoo2

  • 1Division of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma 949-7302, Niigata, Japan. kandatatsuo@gmail.com.

World Journal of Hepatology
|May 1, 2025
PubMed
Summary

Hepatitis E virus (HEV) infection can cause severe jaundice and prolonged cholestasis, especially in individuals with specific genetic variants affecting bile transport. These genetic factors may increase the risk of severe HEV infection outcomes.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Hepatitis E virus (HEV) infection leads to acute and chronic hepatitis, with potential extrahepatic manifestations.
  • HEV is associated with biliary-pancreatic diseases and atypical presentations like severe jaundice and prolonged cholestasis.
Keywords:
CholestasisFarnesoid X receptorGenomic mutationsHepatitis E virusJaundice

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