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Updated: May 9, 2025

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Cardiometabolic multimorbidity and frailty in middle-aged and older adults: a cross-nationally harmonized study

Kunyan Zhou1, Ao Wang1, Ke Yi1

  • 1Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in Public Health
|May 1, 2025
PubMed

Insights

Multiple cardiometabolic diseases significantly worsen frailty in older adults. Stroke has the most profound effect, underscoring the need for early intervention to manage these conditions and their impact on aging populations.

Area of Science:

  • Gerontology
  • Cardiology
  • Public Health

Background:

  • Cardiometabolic diseases (CMD) are common in aging populations.
  • CMD are closely associated with frailty.
  • The cumulative effect of multiple CMD on frailty is not well understood.

Purpose of the Study:

  • To investigate the correlation between the number of cardiometabolic diseases and frailty severity.
  • To analyze the impact of specific cardiometabolic diseases on frailty.

Main Methods:

  • Utilized data from four international cohorts (HRS, CHARLS, ELSA, SHARE).
  • Assessed frailty using a standardized frailty index.
  • Employed linear regression models to determine associations between CMD and frailty.

Main Results:

  • Increased number of CMD significantly correlated with higher frailty index scores.
  • Stroke demonstrated the most substantial impact on frailty severity.
  • The presence of multiple CMD amplified frailty symptoms.

Conclusions:

  • Multiple cardiometabolic diseases have a compounded, significant negative impact on frailty.
  • Early intervention strategies are crucial for managing CMD and mitigating frailty in older adults.
Abstract

Keywords:
diabetesfrailty indexheart diseasemiddle-aged and older peoplemulticohort cardiometabolic diseasesstroke

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