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Related Experiment Video

Updated: May 13, 2026

Microfluidic Chip Fabrication and Method to Detect Influenza

Microfluidic Chip Fabrication and Method to Detect Influenza

Published on: March 26, 2013

Non-invasive micro-test technology and applications.

Kai Sun¹, Yunqi Liu^2,3, Yanshu Pan⁴

¹College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.

Biophysics Reports

|May 1, 2025

Summary

Non-invasive micro-test technology (NMT) measures ion and molecule fluxes with high sensitivity. This review covers NMT applications in diverse fields, highlighting its role in understanding homeostasis and physiological functions.

Keywords:

Calcium signature H+-ATPase Ionic homeostasis Non-invasive micro-test technology Physiology Transmembrane transport

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Area of Science:

Biotechnology
Physiology
Environmental Science

Background:

Dynamic ionic/molecular concentration gradients are crucial for biological processes.
Understanding transmembrane transport is key to cellular function.
Existing methods may lack the required sensitivity or non-invasive nature.

Purpose of the Study:

To review the applications of Non-invasive micro-test technology (NMT).
To highlight NMT's capability in measuring ion and molecule fluxes.
To showcase NMT's utility across various scientific disciplines.

Main Methods:

Non-invasive micro-test technology (NMT) measures fluxes of ions and small molecules.
Measurements are performed in liquid media in 1D, 2D, or 3D.
High sensitivity up to pico- or femto-moles per cm² per second is achieved.

Main Results:

NMT enables the study of metabolism, signal transduction, and gene/protein functions.
It reveals physiological functions related to transmembrane ionic/molecular activities.
Data on ion and/or molecule homeostasis (IMH) has been collected.

Conclusions:

NMT is a versatile tool for studying dynamic biological processes.
Its high sensitivity and non-invasive nature make it valuable across multiple scientific fields.
NMT provides critical insights into ion and molecule homeostasis in living systems.