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Delaying liver aging: Analysis of structural and functional alterations
Yu-Qin Yao1, Qiong-Yue Cao1, Zheng Li2
1College of Health Sciences, School of Life Sciences, Jiangsu Normal University, Xuzhou 221000, Jiangsu Province, China.
World Journal of Gastroenterology
|May 1, 2025
Summary
Liver aging reduces size and circulation, impairing function. Lifestyle changes like diet and exercise can decelerate liver aging and prevent disease.
Area of Science:
- Gerontology
- Hepatology
- Molecular Biology
Background:
- Liver aging is characterized by reduced size and blood flow, impacting overall health.
- Aging-related physiological changes can increase susceptibility to liver diseases.
- Key factors include impaired lipid metabolism, chronic inflammation, mitochondrial dysfunction, and telomere shortening.
Discussion:
- Accumulated cellular damage, such as hepatic steatosis, negatively affects liver regeneration and metabolic functions.
- Understanding structural and functional liver aging mechanisms is crucial for developing interventions.
- Public awareness of anti-aging strategies for the liver is essential for promoting healthy aging.
Key Insights:
- Liver aging involves significant structural and functional decline.
- Hepatic steatosis is a consequence of aging-related cellular changes.
- Interventions targeting liver aging mechanisms are vital for disease prevention.
Outlook:
- Lifestyle modifications, including diet and exercise, are effective in decelerating liver aging.
- Further research into liver aging mechanisms can identify novel therapeutic targets.
- Promoting healthy aging strategies can enhance liver health in elderly populations.
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