Related Experiment Video

Updated: May 9, 2025

Modified Annexin V/Propidium Iodide Apoptosis Assay For Accurate Assessment of Cell Death
07:34

Modified Annexin V/Propidium Iodide Apoptosis Assay For Accurate Assessment of Cell Death

Published on: April 24, 2011

102.9K

Annexin A: Cell Death, Inflammation, and Translational Medicine

Zibing Qian1, Ziyi Li1, Xuebin Peng2

  • 1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.

Journal of Inflammation Research
|May 1, 2025
PubMed

Insights

Annexin A regulates calcium-dependent cell death and inflammation. This review explores its roles in various cell death pathways and potential therapeutic applications.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • Annexin superfamily proteins are calcium-dependent phospholipid binders involved in membrane events.
  • Annexin A, found in vertebrates, plays a role in multiple regulated cell death (RCD) pathways like apoptosis, pyroptosis, and NETosis.
  • Inflammation is a critical factor in cell death, making Annexin A's inflammatory roles a significant research area.

Purpose of the Study:

  • To review the regulatory functions of Annexin A in RCD and inflammation.
  • To discuss the development of Annexin A-targeted therapies in translational medicine.
  • To analyze the application of animal models in studying Annexin A's roles and to identify future research directions.

Main Methods:

  • Literature review of studies on Annexin A, RCD, and inflammation.
  • Analysis of translational medicine approaches targeting Annexin A.
  • Evaluation of animal models used in Annexin A research.

Main Results:

  • Annexin A is a key regulator in diverse RCD pathways, including apoptosis, pyroptosis, and NETosis.
  • Annexin A significantly influences inflammatory processes, impacting cell death outcomes.
  • Targeted therapies and animal models are crucial for understanding and treating Annexin A-related conditions.

Conclusions:

  • Annexin A's multifaceted roles in RCD and inflammation present therapeutic opportunities.
  • Further research using advanced models is needed to overcome current diagnostic and therapeutic challenges.
  • Translational medicine holds promise for developing novel strategies targeting Annexin A.
Keywords:
Annexin Ainflammationregulated cell deathtranslational medicine

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