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Related Experiment Video

Updated: May 9, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Alopecic Scalp Cysts Following Isotretinoin.

Agnes Lim¹, Wei-Liang Koh¹, Yong-Kwang Tay¹

¹Department of Dermatology, Changi General Hospital, Singapore.

International Journal of Trichology

|May 1, 2025

Summary

A rare side effect of isotretinoin (acne medication) is scalp cysts. This case report details a young woman who developed these cysts and received successful treatment, highlighting the importance of clinician awareness.

Keywords:

Acne alopecia isotretinoin pseudo-acne fulminans scalp cyst

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Microscopic Cyst Resection for the Treatment of Patients Diagnosed with Epididymal Cyst

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Published on: March 31, 2023

Area of Science:

Dermatology
Dermatopathology

Background:

Isotretinoin is a widely prescribed medication for severe acne.
Common side effects include xerosis, myalgia, and hypertriglyceridemia.
Scalp cysts are not a commonly reported side effect of isotretinoin.

Observation:

A young female patient developed alopecic scalp cysts after three weeks of isotretinoin therapy for facial nodulocystic acne.
Dermoscopic examination revealed patent hair follicular openings with scattered black dots and open comedones.
The clinical presentation suggested pseudo-acne fulminans.

Findings:

The patient was treated with oral prednisolone, oral erythromycin, and topical minoxidil.
The treatment resulted in the resolution of scalp cysts and significant hair regrowth.
This case highlights a previously unreported adverse effect of isotretinoin.

Implications:

Dermatologists should be aware of the potential for scalp cyst formation as an unintended outcome of isotretinoin therapy.
Early recognition and appropriate management, including treatments like corticosteroids and minoxidil, are crucial for favorable outcomes.
This finding is particularly relevant for acne patients presenting with scalp comedones.