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Updated: May 9, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Evaluation of Treatment Response and Survival Outcomes in Anaplastic Thyroid Cancer Patients Following Surgery With

Hossein Negahban1, Nazila Heidari2,3, Amirhossein Heidari3,4

  • 1Cancer Research Center of Cancer institute Tehran University of Medical Sciences Tehran Iran.

Health Science Reports
|May 1, 2025
PubMed
Abstract

Insights

Surgery combined with adjuvant therapies offers benefits for resectable anaplastic thyroid carcinoma (ATC). However, optimal treatment for advanced stages (IVC) remains controversial, requiring further investigation for improved patient survival.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Thyroid Cancer Research

Background:

  • Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive malignancy with a poor prognosis.
  • Current treatment strategies lack standardization, hindering improvements in patient survival.

Purpose of the Study:

  • To evaluate the effectiveness of surgical interventions, alone or in combination with other treatments, for anaplastic thyroid carcinoma.

Main Methods:

  • Systematic review of retrospective English studies published until June 2023, indexed in PubMed, Web of Science, and Scopus.
  • Adherence to PRISMA guidelines for systematic reviews and meta-analyses.
  • Citation search of included articles.

Main Results:

  • Analysis of 56 articles involving 16,246 ATC patients.
  • Combination of surgery and adjuvant chemoradiotherapy is the most effective option for resectable ATC.
  • Surgery's role in stage IVC ATC is debated, and treatment efficacy can be influenced by patient factors like tumor size.

Conclusions:

  • Stage IVA and IVB resectable ATC may benefit from surgery plus adjuvant therapies.
  • Treatment effectiveness and adjuvant therapy selection for stage IVC ATC remain controversial areas requiring further research.
Keywords:
anaplastic thyroid cancersurgerysystematic reviewthyroid neoplasmthyroidectomy

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