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Updated: May 9, 2025

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
A window into the brain: multimodal MRI assessment of vascular cognitive impairment
Changjun Ma1,2,3, Ailian Liu4, Jiahui Liu2,3
1School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China.
Abstract:
Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer's disease (AD) in neuro diseases. The advancement of medical imaging technology, particularly magnetic resonance imaging (MRI), has enabled the early detection of structural, functional, metabolic, and cerebral connectivity alterations in individuals with VCI. This paper examines the utility of multimodal MRI in evaluating structural changes in the cerebral cortex, integrity of white matter fiber tracts, alterations in the blood-brain barrier (BBB) and glymphatic system (GS) activity, alteration of neurovascular coupling function, assessment of brain connectivity, and assessment of metabolic changes in patients with VCI.
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