Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.

Depression and anxiety·2026
Same author

Development of a Flexible Microneedle Array Electrode with a High Signal-to-Noise Ratio for Surface Bioelectrical Signal Recording.

Biosensors·2026
Same author

Task demand modulates somatosensory-frontoparietal networks during delay and retrieval periods in tactile working memory.

Communications biology·2026
Same author

Regulatory alignment in FDA expedited pathways for infectious diseases: a decadal review with predictive modeling insights.

Scientific reports·2025
Same author

Over-the-Counter Antibiotics in Vietnam: A Public Health Crisis.

Hospital pharmacy·2025
Same author

Regulation of Somatosensory Temporal Discrimination Threshold Through Motor Training: An EEG and Kinematics Study.

CNS neuroscience & therapeutics·2025

Related Experiment Video

Updated: May 14, 2025

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.0K

Gamma Transcranial Alternating Current Stimulation Enhances Working Memory Ability in Healthy People: An EEG

Binbin Gao1, Jinyan Zhang2, Jianxu Zhang2

  • 1School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

Brain Sciences
|May 1, 2025
PubMed
Summary

Gamma transcranial alternating current stimulation (γ-tACS) enhances working memory (WM) performance. This study used EEG microstate analysis to reveal how γ-tACS alters brain dynamics, improving cognitive function.

Keywords:
microstateresting-state EEGworking memoryγ-tACS

More Related Videos

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

13.5K
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

13.9K

Related Experiment Videos

Last Updated: May 14, 2025

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.0K
Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

13.5K
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

13.9K

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Brain Stimulation

Background:

  • Working memory (WM) is crucial for higher cognitive functions.
  • Transcranial alternating current stimulation (tACS) modulates brain activity and cognition.
  • Gamma tACS (γ-tACS) shows promise for WM enhancement, but mechanisms are unclear.

Purpose of the Study:

  • Investigate the neural mechanisms of γ-tACS effects on WM performance using EEG microstate analysis.
  • Evaluate the impact of different γ-tACS waveforms (sine and triangular) on WM tasks.
  • Correlate changes in brain dynamics with WM performance improvements.

Main Methods:

  • Utilized electroencephalogram (EEG) microstate analysis to examine brain activity.
  • Administered sine and triangular γ-tACS, plus sham stimulation, to 104 healthy participants.
  • Assessed performance on two-back and three-back working memory tasks pre- and post-stimulation.

Main Results:

  • γ-tACS significantly improved performance on both WM tasks.
  • Triangular γ-tACS demonstrated superior accuracy improvement in the three-back task compared to sham.
  • γ-tACS modulated EEG microstates (downregulated C, upregulated D and B), correlating with faster reaction times.

Conclusions:

  • EEG microstate analysis is effective for assessing γ-tACS-induced global brain activity changes.
  • This study advances understanding of γ-tACS mechanisms in modulating working memory.
  • Findings highlight the potential of γ-tACS for cognitive enhancement.