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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Overview of Protein Metabolism01:21

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Protein Absorption01:12

Protein Absorption

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Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
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[Food protein-induced enterocolitis syndrome].

Zsuzsa Andrea Domokos1, Kirsten Skamstrup Hansen2, Lene Heise Garvey1

  • 1Klinik for Allergi, Afdeling for Allergi, Hud og Kønssygdomme, Københavns Universitetshospital - Herlev og Gentofte Hospital.

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Summary
This summary is machine-generated.

Food protein-induced enterocolitis syndrome (FPIES), a non-IgE hypersensitivity, can affect adults. This case report highlights FPIES as a crucial diagnosis in adults experiencing gastrointestinal distress after food ingestion.

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Area of Science:

  • Gastroenterology
  • Allergy and Immunology

Background:

  • Food protein-induced enterocolitis syndrome (FPIES) is typically diagnosed in infants.
  • It is characterized as a non-immunoglobulin E (IgE)-mediated hypersensitivity reaction to food proteins.

Purpose of the Study:

  • To report two adult cases of FPIES.
  • To emphasize that FPIES should be considered in adult patients presenting with symptoms suggestive of food allergy.

Main Methods:

  • Case report detailing clinical presentation of two adult women.
  • Diagnostic evaluation included clinical history and exclusion of other allergic conditions through allergy testing.

Main Results:

  • Both patients experienced recurrent severe vomiting and diarrhea hours after consuming mussels.
  • Diagnosis of FPIES was established based on clinical history and negative allergy tests.

Conclusions:

  • FPIES can manifest in adult patients.
  • FPIES is an important differential diagnosis for adults with suspected food allergies and gastrointestinal symptoms.