Related Experiment Video

Updated: May 15, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

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Rhabdomyolysis in Children: A State-of-the-Art Review

Manson Chon In Kuok1, Winnie Kwai Yu Chan1

  • 1Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong, China.

Children (Basel, Switzerland)
|May 1, 2025
PubMed

Insights

Pediatric rhabdomyolysis, a serious muscle breakdown condition, presents unique challenges. This review covers causes, complications, and management, including novel hemoadsorption therapies for myoglobin removal.

Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine
  • Biochemistry

Background:

  • Rhabdomyolysis involves skeletal muscle breakdown, releasing myoglobin and causing kidney injury.
  • Pediatric rhabdomyolysis is rare but severe, with distinct challenges compared to adults.
  • Acute kidney injury (AKI) is a major complication, sometimes requiring kidney replacement therapy.

Purpose of the Study:

  • To review the pathophysiology, etiologies, complications, and outcomes of pediatric rhabdomyolysis.
  • To summarize emerging evidence on hemoadsorption for myoglobin removal.
  • To propose a management framework for pediatric rhabdomyolysis.

Main Methods:

  • Literature review focusing on pediatric rhabdomyolysis.
  • Analysis of pathophysiology and clinical manifestations.
  • Evaluation of treatment strategies, including hemoadsorption.

Main Results:

  • Pediatric rhabdomyolysis has unique etiologies and clinical presentations.
  • Myoglobin release is a key factor in AKI.
  • Hemoadsorption shows promise for myoglobin clearance.

Conclusions:

  • Effective management requires understanding pediatric-specific factors.
  • Hemoadsorption offers a potential adjunctive therapy for severe cases.
  • A systematic approach is crucial for optimizing patient outcomes.

Keywords:
acute kidney injurycreatine kinasemyositisrhabdomyolysis

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