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Updated: May 9, 2025
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
[Rise in incidence of early-onset colorectal cancer in the Netherlands: cause for concern?]
Marloes A G Elferink1,2, Laskarina J K Galanos1, Femke P C Sijtsma1
1Integraal Kankercentrum Nederland, afd. Research & Development, Utrecht.
Objective:
To describe trends in incidence of early-onset colorectal cancer in the Netherlands.
Design:
Observational research.
Method:
We selected colorectal cancer patients aged 15 to 49 years, diagnosed between 1989-2023, from the Netherlands Cancer Registry (NCR). We calculated incidence rates and determined changes in trends using Joinpoint regression analyses. Furthermore, we made a prediction of the number of early-onset colorectal cancer patients in 2035.
Results:
The number of new early-onset colorectal cancer patients has increased; from 6.3 per 100,000 in 1998 to 9.3 per 100,000 in 2023 (Annual Percentage Change 1.41% (95% confidence interval 1.18-1.71)). This incidence is expected to increase further in the future, reaching between 629 and 871 cases by 2035.
Conclusion:
There is an increase in the incidence of early-onset colorectal cancer in the Netherlands which appears to persist over the next 10 years. Further research is needed to identify the causes of this increase.
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