Structural and functional optimization of COF-coated stirring bars for environmental monitoring and biological sample
Lianzhi Wang1, Xixi Lian2, Jianing Sun2
1School of Chemistry and Environmental Engineering, Hubei Minzu University, No. 39 Xueyuan Road, Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, 445000, China. wlz1269@163.com.
Abstract:
In this study, a series of covalent organic framework (COF)-coated stirring bars-COF-a, COF-b, and COF-c-were innovatively designed and evaluated for the efficient extraction of estrogens from complex environmental and biological samples. The most notable advancement lies in the successful application of COF-c, which exhibited exceptional adsorption capacity, thermal stability, and reusability. Unlike conventional PDMS coatings, COF-c demonstrated enhanced performance in capturing estrogens from actual meat samples, achieving high recovery rates (78.6-119.3%) and maintaining consistent extraction efficiency over multiple cycles. These findings highlight the structural advantages of COF-c, such as its larger pore volume and strong π-π and hydrogen bonding interactions with target molecules. This work underscores the potential of COF-c as a next-generation SBSE coating material, offering a highly selective, thermally stable, and reusable platform for trace hormone analysis in complex matrices.
