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Updated: Jul 10, 2026

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Published on: June 17, 2015
Role of Ion Channels in Alzheimer's Disease Pathophysiology
Ranjit Bhoi1,2, Tuhina Mitra1,2, Kallam Tejaswi1,2
1School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, 752050, India.
Abstract:
Ion channels play an integral role in the normal functioning of the brain. They regulate neuronal electrical properties like synaptic activity, generation of action potentials, maintenance of resting membrane potential and neuronal plasticity, and modulate the physiology of non-neuronal cells like astrocytes and microglia. Dysregulation of ionic homeostasis and channelopathies are associated with various neurological disorders, including Alzheimer's disease (AD). Several families of ion channels are associated with AD pathophysiology and progression. In this review, we outline the current research centered around ion channel dysregulation during AD and discuss briefly the possibility of using ion channels as therapeutic targets.
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